THYMOSIN ALPHA-1 10MG

£28.00

Thymosin Alpha-1 is a synthetic immunomodulatory peptide developed for experimental investigation of T-cell signalling, immune system regulation, and peptide-mediated cellular communication pathways.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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Thymosin Alpha-1

Synonyms / Designations: Thymosin Alpha-1, Tα1, Thymosin α1, Thymalfasin
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55
Molecular Weight: ~3108.32 g/mol
Peptide Length: 28 amino acids
Peptide Type: Synthetic immunomodulatory peptide (thymic peptide analogue)
Purity: ≥ 99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Thymosin Alpha-1 is a synthetic 28-amino-acid peptide corresponding to an active fragment of the endogenous thymic hormone prothymosin-α. It is widely used in experimental research to investigate immune system regulation, peptide–receptor interactions, and intracellular signalling pathways involved in innate and adaptive immunity.

In biochemical and cellular research systems, Thymosin Alpha-1 has been shown to modulate immune-related signalling pathways, including those associated with antigen presentation, cytokine expression, and T-cell differentiation. Experimental studies commonly examine its influence on toll-like receptor signalling, NF-κB activation, and interferon-related pathways. Observed molecular responses are dependent on concentration, exposure duration, and experimental model.

Applications in Research

As a molecular probe for studying immune modulation and thymic peptide signalling.
Investigation of innate and adaptive immune pathway regulation in cellular models.
In vitro studies examining cytokine signalling, antigen presentation, and T-cell activation.
Use as a reference peptide in immunology, inflammation, and host-defence research.

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic.
Reconstitute in sterile water or appropriate buffered aqueous solution.
Avoid vigorous agitation during dissolution.
Filter sterilize if required (e.g. 0.22 µm) prior to use.
Aliquot and store reconstituted solutions at –20 °C or lower.
Avoid repeated freeze–thaw cycles.

Precautions & Notes

Experimental behaviour is influenced by immune cell type, receptor expression, concentration, and exposure duration.
Buffer composition, pH, and ionic strength may affect peptide stability.
Appropriate controls are recommended.
Intended strictly for laboratory research use.

References

Goldstein A.L. et al. Thymosin alpha 1: biological activity and clinical applications. Annals of the New York Academy of Sciences, 2007.
https://pubmed.ncbi.nlm.nih.gov/17660844/

Romani L. et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance. Blood, 2004.
https://pubmed.ncbi.nlm.nih.gov/15026312/

Garaci E. et al. Thymosin alpha 1 in immune regulation. International Journal of Immunopharmacology, 1998.
https://pubmed.ncbi.nlm.nih.gov/9802921/

Keywords: Thymosin Alpha-1, Tα1, Thymalfasin, Immunomodulatory Peptide, Synthetic Thymic Peptide