PT-141 10MG

£25.00

PT-141 is a specialised synthetic melanocortin peptide developed for advanced scientific exploration of melanocortin receptor signalling (MC3R / MC4R) and central neuropeptide pathways, commonly studied in models of motivation, reward, and neuroendocrine signalling.

Batch tested Purity: ≥ 98% (HPLC, typical)
CAS Number: 189691-06-3
Molecular Formula: C50H68N14O10

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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PT-141

Synonyms / Designations: PT-141, Bremelanotide, Melanotan II analogue
CAS Number: 189691-06-3
Molecular Formula: C50H68N14O10
Molecular Weight: ~1025.18 g/mol
Peptide Length: 7 amino acids (cyclic peptide)
Peptide Type: Synthetic melanocortin receptor agonist
Purity: ≥ 99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

PT-141 is a synthetic cyclic heptapeptide derived from melanocortin peptides and developed for experimental investigation of melanocortin receptor-mediated signalling pathways. It is structurally related to Melanotan II but exhibits distinct receptor selectivity and signalling characteristics.

In biochemical and cellular research systems, PT-141 interacts primarily with melanocortin receptors (MC1R, MC3R, MC4R), initiating intracellular signalling cascades associated with cAMP production and downstream transcriptional regulation. Experimental studies investigate receptor binding affinity, signalling bias, and comparative behaviour relative to other melanocortin analogues. Observed molecular responses depend on concentration, exposure duration, and experimental model.

Applications in Research

As a molecular probe for studying melanocortin receptor signalling
Investigation of GPCR-mediated intracellular signalling pathways
In vitro studies examining receptor selectivity and peptide stability
Use as a reference compound in neuroendocrine and peptide signalling research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution
Avoid vigorous agitation during dissolution
Filter sterilize if required prior to use
Aliquot and store reconstituted solutions at –20 °C or lower
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental behaviour is influenced by receptor expression, peptide concentration, and exposure duration
Buffer composition, pH, and ionic strength may affect peptide stability
Appropriate controls are recommended to distinguish receptor-specific effects
Intended strictly for laboratory research use

References

Hadley M.E. et al. Melanocortin peptides and receptors. Endocrine Reviews, 1999.
https://pubmed.ncbi.nlm.nih.gov/10447403/

Wessells H. et al. Melanocortin receptor agonists and signalling mechanisms. Journal of Peptide Research, 2003.
https://pubmed.ncbi.nlm.nih.gov/12622733/

Cone R.D. The melanocortin system and GPCR signalling. Nature Reviews Neuroscience, 2006.
https://pubmed.ncbi.nlm.nih.gov/16755264/

Keywords: PT-141, Bremelanotide, Melanocortin Agonist, Synthetic Peptide, GPCR Signalling