SEMAX 10MG

£40.00

Semax is a specialised synthetic heptapeptide developed for advanced scientific exploration of neurotrophin signalling and melanocortin (ACTH-fragment) related pathways, commonly studied in models of neuroprotection, cognition, and stress-response biology.

Batch tested Purity: ≥ 98% (HPLC, typical)
CAS Number: 80714-61-0
Molecular Formula: C₃₇H₅₁N₉O₁₀S

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
Contact us for Wholesale Orders

Semax

Synonyms / Designations: Semax, ACTH(4–7) Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro
CAS Number: 80714-61-0
Molecular Formula: C37H51N9O10S
Molecular Weight: ~813.92 g/mol
Peptide Length: 7 amino acids
Peptide Type: Synthetic neuropeptide (ACTH(4–7) analogue)
Purity: ≥ 99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone fragment ACTH(4–7), modified with a C-terminal Pro–Gly–Pro sequence to enhance metabolic stability. It was developed for experimental investigation of neuropeptide signalling, neuromodulation, and central nervous system regulatory pathways.

In biochemical and cellular research systems, Semax has been studied for its interactions with neuronal signalling pathways associated with neurotrophic factors, synaptic plasticity, and stress-response regulation. Experimental models commonly investigate its effects on intracellular signalling cascades, gene expression related to neurotrophins, and modulation of neurotransmitter systems. Observed molecular responses are dependent on experimental design, concentration, and model system.

Applications in Research

As a molecular probe for studying neuropeptide-mediated signalling pathways
Investigation of neuronal plasticity, neurotrophic signalling, and stress-related molecular mechanisms
In vitro and in vivo research examining peptide stability and CNS-active peptide analogues
Use as a reference compound in neurobiology and peptide signalling research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) prior to use
Aliquot and store reconstituted solutions at –20 °C or lower
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental behaviour of Semax is influenced by neuronal model, receptor expression, peptide concentration, and exposure duration
Buffer composition, pH, and ionic strength may affect peptide stability
Appropriate controls are recommended to distinguish specific from non-specific effects
Intended strictly for laboratory research use; not for human or veterinary application

References

Ashmarin I.P. et al. Semax as a regulator of neurotrophic factors. Neuroscience and Behavioral Physiology, 1997.
https://pubmed.ncbi.nlm.nih.gov/9404683/

Gusev E.I. et al. Neuropeptide Semax in experimental models of brain function. Neuroscience and Behavioral Physiology, 2000.
https://pubmed.ncbi.nlm.nih.gov/10739407/

Myasoedov N.F. et al. ACTH-derived peptides and central nervous system regulation. Journal of Peptide Science, 2011.
https://pubmed.ncbi.nlm.nih.gov/21491577/

Keywords: Semax, ACTH(4–7), Synthetic Neuropeptide, CNS Signalling, Neurotrophic Peptide