PANCRAGEN 10MG

£45.00

Pancragen is a synthetic tetrapeptide used as a research tool to investigate tissue-specific gene-expression regulation in pancreatic experimental systems.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: N/A
Molecular Formula: C26H36N6O9 (free acid); C26H37N7O8 (amide form)

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
Contact us for Wholesale Orders

Pancragen

Synonyms / Designations: Pancragen; KEDW; Lys-Glu-Asp-Trp; pancreatic peptide bioregulator (literature compound is the amidated KEDW-NH2)
Amino Acid Sequence: Lys-Glu-Asp-Trp (KEDW); literature uses the C-terminal amide KEDW-NH2
CAS Number: N/A
Molecular Formula: C26H36N6O9 (free acid); C26H37N7O8 (amide form)
Molecular Weight: 576.25 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Pancragen (KEDW / KEDW-NH2) is studied in vitro as a pancreas-directed short-peptide probe. In aged human pancreatic cell cultures it has been reported to increase expression of proliferation markers (Ki-67, PCNA) and matrix metalloproteinases, and to alter apoptosis-associated proteins, used experimentally to study acinar/islet differentiation and cell-renewal signalling.

It functions as a molecular tool for probing transcriptional control of pancreatic endocrine/exocrine differentiation and glucose–insulin axis biomarkers in cellular and preclinical models. Observed effects depend on concentration, model system and exposure conditions; no physiological outcome is implied.

Applications in Research

In-vitro study of pancreatic acinar / islet cell differentiation and proliferation/apoptosis markers
Preclinical (rodent / aged-primate) models of pancreatic functional decline
Investigation of peptide effects on glucose–insulin axis biomarkers in experimental systems
Probe for tissue-specific transcriptional regulation

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) prior to use
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
Avoid repeated freeze–thaw cycles

Precautions & Notes

Confirm whether the supplied material is the free-acid (KEDW) or amidated (KEDW-NH2) form against the batch CoA; molecular weights differ
Experimental behaviour is dependent on concentration, model system and exposure conditions
Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
Intended strictly for laboratory research use; not for human or veterinary application

References

Khavinson VKh, et al. Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide. Bull Exp Biol Med. 2010.
https://pubmed.ncbi.nlm.nih.gov/21246099/

Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys. Adv Gerontol.
https://pubmed.ncbi.nlm.nih.gov/25946840/

PubChem Compound Summary, CID 68451868 (H-Lys-Glu-Asp-Trp-NH2).
https://pubchem.ncbi.nlm.nih.gov/compound/68451868

Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053

Keywords: Pancragen, KEDW, pancreatic peptide bioregulator, synthetic tetrapeptide