TESTAGEN 20mg

£45.00

Testagen is a synthetic tetrapeptide used as a research tool to investigate tissue-specific gene-expression regulation in reproductive-tissue experimental systems.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: N/A
Molecular Formula: C17H29N5O9

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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Testagen

Synonyms / Designations: Testagen; KEDG; Lys-Glu-Asp-Gly; testis peptide bioregulator (Khavinson family)
Amino Acid Sequence: Lys-Glu-Asp-Gly (KEDG)
CAS Number: N/A
Molecular Formula: C17H29N5O9
Molecular Weight: 447.44 g/mol
Purity: ≥ 99% (HPLC)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Testagen (KEDG) is studied in vitro as a testis-directed short-peptide probe. Within the Khavinson framework it is proposed to act at the chromatin/transcriptional level to modulate expression of genes associated with testicular (Leydig/Sertoli) cell function in experimental systems.

It is used as a tool to examine peptide-driven regulation of proliferation and steroidogenesis-associated gene expression in organotypic cultures and rodent models, and as a comparator in tissue-specificity panels. Observed effects depend on concentration, model system, and exposure conditions; no physiological outcome is implied.

Applications in Research

In vitro study of testicular cell gene-expression and proliferation markers.
Preclinical rodent models of age-related reproductive tissue change.
Tissue-specificity comparison across Khavinson bioregulators.
Materials science research: KEDG has also been characterised as a copper corrosion inhibitor in saline environments.

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic.
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements.
Avoid vigorous agitation during dissolution.
Filter sterilize if required (e.g. 0.22 µm) prior to use.
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation.
Avoid repeated freeze–thaw cycles.

Precautions & Notes

Experimental behaviour is dependent on concentration, model system, and exposure conditions.
Avoid performance or hormonal interpretation; appropriate experimental controls are recommended.
Prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability.
Intended strictly for laboratory research use; not for human or veterinary application.

References

Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053

Khavinson VKh. Peptides and ageing. Neuro Endocrinol Lett. 2002;23(Suppl 3):11–144.
https://pubmed.ncbi.nlm.nih.gov/12374906/

The inhibitory effect and adsorption properties of Testagen peptide on copper surfaces in saline environments. Molecules. 2024.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12348504/

Keywords: Testagen, KEDG, testis peptide bioregulator, synthetic tetrapeptide