CORTAGEN 20MG

£45.00

Cortagen is a synthetic tetrapeptide used as a research tool to investigate tissue-specific gene-expression regulation in nervous-tissue experimental systems.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: N/A
Molecular Formula: C17H26N4O9

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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Cortagen

Synonyms / Designations: Cortagen; AEDP; brain cortex peptide bioregulator; synthetic short-peptide analogue of Cortexin
Amino Acid Sequence: Ala-Glu-Asp-Pro (AEDP)
CAS Number: N/A
Molecular Formula: C17H26N4O9
Molecular Weight: 430.41 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Cortagen is a short synthetic tetrapeptide, designed on the basis of amino-acid analysis of the cortical polypeptide preparation Cortexin, used as a molecular probe for studying tissue-specific gene regulation in nervous-tissue model systems. In experimental settings it is applied to neuronal and glial cultures and to peripheral-nerve regeneration models to examine neurotrophic gene expression, cell proliferation and neurite outgrowth.

In line with the Khavinson short-peptide paradigm, Cortagen is studied as a candidate cell-penetrating regulator that may bind DNA/histones and modulate promoter activity. It serves as a research tool for probing transcriptional mechanisms in experimental neuroscience preparations; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

Preclinical rodent peripheral-nerve regeneration models (e.g. sciatic-nerve transection)
In-vitro neuronal / glial culture gene-expression and neurite-outgrowth assays
Cellular models of neuroprotection and oxidative stress
Probe for short-peptide transcriptional regulation in neural tissue

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) prior to use
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental behaviour is dependent on concentration, model system and exposure conditions
Appropriate experimental controls are recommended
Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
Intended strictly for laboratory research use; not for human or veterinary application

References

Turchaninova VV, Kolosova LI, et al. Effect of tetrapeptide cortagen on regeneration of sciatic nerve. Bull Exp Biol Med.
https://link.springer.com/article/10.1007/BF02682018

Khavinson VKh, Linkova NS, et al. Short cell-penetrating peptides: a model of interactions with gene promoter sites.
https://pubmed.ncbi.nlm.nih.gov/23484211/

Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053

Keywords: Cortagen, AEDP, brain cortex peptide bioregulator, synthetic tetrapeptide