CARTALEX 20MG

£45.00

Cartalax is a synthetic tripeptide used as a research tool to investigate tissue-specific gene-expression regulation in cartilage and connective-tissue experimental systems.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: N/A
Molecular Formula: C12H19N3O8

Guaranteed Safe Checkout

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
Contact us for Wholesale Orders

Cartalax

Synonyms / Designations: Cartalax; AED; cartilage / connective-tissue peptide bioregulator
Amino Acid Sequence: Ala-Glu-Asp (AED)
CAS Number: N/A
Molecular Formula: C12H19N3O8
Molecular Weight: 333.30 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Cartalax is a short synthetic tripeptide used as a molecular probe for studying tissue-specific gene regulation in cartilage and connective-tissue model systems. In chondrocyte and fibroblast cultures it has been used to examine effects on cell proliferation, apoptosis and expression of extracellular-matrix genes (e.g. type II collagen, aggrecan).

In molecular-docking work within the Khavinson model, the AED motif is assigned to a specific promoter site, supporting its use as a research probe for putative short-peptide / DNA-promoter interactions. It is studied as a candidate transcriptional regulator in experimental musculoskeletal systems; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

In-vitro chondrocyte and fibroblast proliferation / apoptosis assays
Extracellular-matrix gene-expression studies (collagen II, aggrecan)
Cellular models of cartilage / connective-tissue aging
Probe for short-peptide promoter-binding studies

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) prior to use
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental behaviour is dependent on concentration, model system and exposure conditions
Appropriate experimental controls are recommended
Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
Intended strictly for laboratory research use; not for human or veterinary application

References

Khavinson VKh, Linkova NS, Tarnovskaya SI, et al. Short cell-penetrating peptides: a model of interactions with gene promoter sites. Bull Exp Biol Med.
https://pubmed.ncbi.nlm.nih.gov/23484211/

Short Peptides Regulate Gene Expression. Bull Exp Biol Med. 2016.
https://link.springer.com/article/10.1007/s10517-016-3596-7

Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053

Keywords: Cartalax, AED, cartilage peptide bioregulator, synthetic tripeptide