BRONCHOGEN 20MG

£38.00

Bronchogen is a synthetic tetrapeptide used as a research tool to investigate tissue-specific gene-expression regulation in bronchial-epithelium experimental systems.

OP Labs formerly Oxford Peptides
Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: N/A
Molecular Formula: C18H30N4O9

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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Bronchogen

Synonyms / Designations: Bronchogen; AEDL; ADEL; lung (bronchial) peptide bioregulator
Amino Acid Sequence: Ala-Asp-Glu-Leu (ADEL, per primary literature; commonly designated AEDL)
CAS Number: N/A
Molecular Formula: C18H30N4O9
Molecular Weight: 446.45 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Bronchogen is a short synthetic tetrapeptide used as a molecular probe for studying tissue-specific regulation of gene expression in bronchial-epithelium model systems. In cultured human bronchial epithelial cells it has been reported to modulate transcription of mucin and surfactant-associated genes (MUC4, MUC5AC, SFTPA1) and to alter levels of proliferation- and apoptosis-associated proteins.

Within the Khavinson short-peptide model, peptides of this class are studied as candidate cell-penetrating regulators that may interact with DNA and chromatin to influence promoter activity. Bronchogen is therefore used to examine putative peptide–DNA interactions and downstream transcriptional readouts in vitro; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

In-vitro modulation of gene/protein expression in human bronchial epithelial cell cultures (MUC4, MUC5AC, SFTPA1, Ki-67, p53)
Cellular models of epithelial proliferation, apoptosis and replicative senescence
Preclinical rodent models of experimental lung inflammation, fibrosis and toxic lung injury
Probe compound for short-peptide / DNA-promoter interaction studies

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) prior to use
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental behaviour is dependent on concentration, model system and exposure conditions
Appropriate experimental controls are recommended
Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
Intended strictly for laboratory research use; not for human or veterinary application

References

Khavinson VKh, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung. 2014;192(5):781-791.
https://pubmed.ncbi.nlm.nih.gov/25015171/

Monaselidze JR, Khavinson VKh, et al. Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bull Exp Biol Med. 2011;150(3):375-377.
https://pubmed.ncbi.nlm.nih.gov/21240358/

Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053

Keywords: Bronchogen, AEDL, lung peptide bioregulator, synthetic tetrapeptide