KPV 5MG

• Batch HPLC tested at 98.5%+ purity.
• Store frozen long term or refrigerated when ready for use.
• Sold for research purposes only.
• Contact us for wholesale orders.

KPV

Synonyms / Designations: KPV, Lys–Pro–Val, α-MSH (11–13), α-Melanocyte-Stimulating Hormone fragment
CAS Number: 67727-97-3
Molecular Formula: C₁₅H₂₆N₄O₄
Molecular Weight: ~342.43 g/mol
Peptide Sequence: Lys–Pro–Val
Peptide Classification: Synthetic tripeptide; α-MSH-derived fragment
Purity: ≥99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

KPV is a synthetic tripeptide corresponding to amino acids 11–13 of α-melanocyte-stimulating hormone (α-MSH). It represents the minimal bioactive fragment commonly utilised in research settings to investigate melanocortin-associated signalling independently of the full-length peptide.

In biochemical and cellular research systems, KPV has been studied for its interactions with melanocortin-related pathways and downstream intracellular signalling mechanisms associated with immune modulation and inflammatory responses. Experimental studies typically examine receptor-independent and receptor-associated signalling effects, transcriptional responses, and peptide stability under controlled conditions. Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to explore peptide-mediated signalling rather than defined biological or physiological outcomes.

Applications in Research

• As a molecular probe for studying melanocortin-related signalling pathways.
• Investigation of peptide-mediated modulation of inflammatory and immune-associated cellular responses.
• In vitro studies examining short peptide signalling and stability.
• Use as a reference compound in melanocortin and α-MSH fragment research.

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic.
• Reconstitute in sterile water or an appropriate buffered aqueous solution depending on assay requirements.
• Avoid vigorous agitation during dissolution.
• Filter sterilise if required (e.g. 0.22 µm) immediately prior to use.
• Aliquot and store reconstituted solutions at –20 °C (or lower).
• Avoid repeated freeze–thaw cycles.

Precautions & Notes

• Experimental behaviour of KPV is influenced by concentration, exposure duration, and experimental model.
• Short peptide fragments may exhibit signalling profiles distinct from parent hormones.
• Buffer composition, pH, and ionic strength may affect peptide stability and assay performance.
• Appropriate controls are recommended to distinguish specific from non-specific effects.
• Intended strictly for laboratory research use; not for human or veterinary application.

References

1. Catania, A. et al. The neuroimmunomodulatory role of melanocortins. Endocrine Reviews, 2004.
   https://pubmed.ncbi.nlm.nih.gov/15082519/
2. Lipton, J. M., Catania, A. Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunology Today, 1997.
   https://pubmed.ncbi.nlm.nih.gov/9368769/
3. Brzoska, T. et al. α-MSH peptides and their receptors: biological functions. Journal of Endocrinology, 2008.
   https://pubmed.ncbi.nlm.nih.gov/18334621/
4. Schiller, P. W. et al. Structure–activity relationships of melanocortin peptides and fragments. Annals of the New York Academy of Sciences.
   https://pubmed.ncbi.nlm.nih.gov/9463824/
5. Getting, S. J. et al. The melanocortin peptide KPV inhibits inflammatory signalling pathways independently of classical melanocortin receptors. Journal of Immunology.
   https://pubmed.ncbi.nlm.nih.gov/12421969/
6. Patel, H. B. et al. Anti-inflammatory effects of melanocortin peptides and minimal active fragments. British Journal of Pharmacology.
   https://pubmed.ncbi.nlm.nih.gov/16783407/
7. PubChem. Lys–Pro–Val (KPV) peptide compound summary.
   https://pubchem.ncbi.nlm.nih.gov/compound/Lys-Pro-Val

Keywords: KPV, Lys–Pro–Val, α-MSH Fragment, Melanocortin Peptide, Synthetic Tripeptide, Peptide Signalling Research.