VIP 10MG

£69.00

VIP is a neuropeptide developed for experimental investigation of neuroendocrine signalling, smooth muscle regulation, and immune-modulatory pathways mediated via VPAC1 and VPAC2 receptors.

Batch tested Purity: ≥ 99 % (HPLC, typical)
CAS Number: 40077-57-4
Peptide Type: Synthetic vasoactive intestinal peptide

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
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VIP (Vasoactive Intestinal Peptide)

Synonyms / Designations: VIP, Vasoactive Intestinal Peptide, Intestinal Vasodilator Peptide
CAS Number: 40077-57-4
Molar Weight: 3325.83 g/mol
Peptide Classification: Synthetic neuropeptide; vasoactive intestinal peptide analogue
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Research Context

Vasoactive Intestinal Peptide (VIP) is a 28–amino acid neuropeptide originally identified in intestinal tissue and later found to be widely distributed in the central and peripheral nervous systems. In research settings, VIP is used as a well-characterised ligand for studying VPAC1 and VPAC2 receptor-mediated signalling pathways.

In biochemical and cellular research models, VIP is investigated for its role in cyclic AMP signalling, smooth muscle relaxation, neuroimmune interactions, and peptide–receptor binding dynamics. Observed molecular responses are dependent on experimental design, concentration, and model system and are used to explore signalling mechanisms rather than defined physiological outcomes.

Applications in Research

As a molecular probe for studying VPAC receptor binding and activation
Investigation of neuroendocrine and neuroimmune signalling pathways
In vitro studies examining peptide-mediated smooth muscle and neuronal signalling
Use as a reference neuropeptide in receptor pharmacology research

Handling, Reconstitution & Stability

Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Aliquot reconstituted solutions to minimise repeated freeze–thaw cycles
Store reconstituted peptide at –20 °C or lower for long-term stability
Protect from prolonged exposure to light and elevated temperatures

Precautions & Notes

Experimental behaviour of VIP is influenced by receptor expression, concentration, and exposure duration
Neuropeptide signalling responses may vary across experimental models
Buffer composition and pH may affect peptide stability and assay performance
Intended strictly for laboratory research use; not for human or veterinary application

References

Said SI, Mutt V. “Polypeptide with broad biological activity: isolation from small intestine.” Science, 1970.
Harmar AJ et al. “International Union of Pharmacology. XVIII. Classification of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.” Pharmacol Rev, 1998.
Delgado M et al. “Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in immune regulation.” Int J Biochem Cell Biol, 2004.

Keywords: VIP, Vasoactive Intestinal Peptide, VPAC Receptor Ligand, Synthetic Neuropeptide