SS 31 10MG

£50.00

SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide developed for experimental investigation of mitochondrial function, oxidative stress modulation, and cardiolipin-associated signalling pathways within cellular bioenergetics research.

Batch tested purity: ≥ 99 % (HPLC, typical)
CAS Number: 736992-21-5
Peptide Type: Synthetic mitochondria-targeting tetrapeptide

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
Contact us for Wholesale Orders

SS-31

Synonyms / Designations: SS-31, Elamipretide, MTP-131, Bendavia
Peptide Type: Synthetic mitochondria-targeting tetrapeptide (aromatic–cationic peptide)
Peptide Sequence: H-D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH2 (often written D-Arg-Dmt-Lys-Phe-NH2)
CAS Number: 736992-21-5
Molecular Weight: ~639.78 g/mol
Salt Note: Molecular formula and molecular weight can vary by counterion (e.g., acetate or hydrochloride salts).
Purity: ≥ 99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water and buffered aqueous solutions (solubility may vary with salt form)

Description & Mechanism

SS-31 (elamipretide) is a synthetic aromatic–cationic tetrapeptide used in research into mitochondrial biology and oxidative stress-associated signalling pathways. In experimental systems, SS-31 has been reported to associate with cardiolipin-rich mitochondrial membranes and is used to investigate how peptide-membrane interactions influence mitochondrial function (e.g., respiration-linked readouts), reactive oxygen species (ROS) handling, and downstream cellular stress responses. Observed outcomes depend on concentration, exposure duration, and model system and are used to study mechanisms rather than defined physiological outcomes.

Applications in Research

Mitochondrial bioenergetics and membrane interaction studies (including cardiolipin-associated systems)
Oxidative stress / ROS signalling investigations in cellular and biochemical models
Models examining mitochondrial dysfunction, membrane potential, and respiration-associated readouts
Reference compound in peptide-mitochondria interaction research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
Aliquot and store reconstituted solutions at –20 °C (or lower) to reduce freeze–thaw cycles
Inspect solutions for precipitation or changes in clarity before use in sensitive assays

Precautions & Notes

Experimental behaviour of SS-31 is influenced by assay format, membrane composition, concentration, and exposure duration
Salt form (e.g., acetate vs hydrochloride) can affect molecular weight, solubility, and handling
Buffer composition, pH, ionic strength, and oxidising environments may affect peptide stability and assay performance
Appropriate controls are recommended to distinguish specific from non-specific effects
Intended strictly for laboratory research use; not for human or veterinary application

References

DrugBank. Elamipretide (DB05016).

https://go.drugbank.com/drugs/DB05016

PubChem. Elamipretide Compound Summary.

https://pubchem.ncbi.nlm.nih.gov/compound/Elamipretide

CAS Common Chemistry. Elamipretide (CAS No. 736992-21-5).

https://commonchemistry.cas.org/detail?cas_rn=736992-21-5

Szeto H.H., Schiller P.W. Novel therapies targeting inner mitochondrial membrane—from discovery to clinical development.

https://pubmed.ncbi.nlm.nih.gov/19007892/

Birk A.V. et al. Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis.

https://pubmed.ncbi.nlm.nih.gov/23699309/

Keywords: SS-31, Elamipretide, MTP-131, Bendavia, Mitochondria-Targeting Peptide, Cardiolipin, Mitochondrial Bioenergetics, Oxidative Stress, Aromatic-Cationic Peptide