AOD9604 5MG

£38.00

AOD9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone, used as a research tool in experimental systems.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: 221231-10-3
Molecular Formula: C78H123N23O23S2

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity.
Store frozen long term or in fridge when ready to be used.
Sold for research purposes only.
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AOD9604

Synonyms / Designations: AOD9604, Synthetic hGH Fragment (176–191), Modified C-terminal Growth Hormone Peptide.
CAS Number: 221231-10-3.
Molecular Formula: C78H123N23O23S2.
Molecular Weight: ~1,815.1 g/mol.
Purity: ≥ 99 % (HPLC).
Appearance: White to off-white lyophilised powder.
Storage: Desiccated, protected from light, stored at –20 °C or below.
Solubility: Soluble in water and buffered aqueous solutions.

Description & Mechanism

AOD9604 is a synthetic peptide derived from the C-terminal fragment (residues 176–191) of human growth hormone (hGH), with sequence modifications introduced to enhance stability and research utility. Unlike full-length growth hormone, AOD9604 does not directly activate the growth hormone receptor but is studied as a discrete molecular fragment with distinct biological activity in experimental systems.

In biochemical and cellular research models, AOD9604 is used to investigate growth hormone–related signalling pathways that are independent of classical GH receptor activation. Preclinical studies have shown that this peptide fragment can influence pathways associated with lipid metabolism and intracellular signalling without eliciting broad growth hormone–mediated effects. Observed outcomes are dependent on experimental context, concentration, and model design, making AOD9604 a useful tool for mechanistic studies examining domain-specific activity of growth hormone–derived peptides.

Applications in Research

As a molecular tool to study growth hormone fragment–specific signalling mechanisms.
Investigation of lipid metabolism–associated pathways in cellular and biochemical models.
In vitro studies examining receptor-independent growth hormone signalling.
Preclinical or ex vivo research exploring structure–function relationships of GH-derived peptides.

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic.
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements.
Avoid vigorous agitation during dissolution.
Filter sterilize if required (e.g. 0.22 µm) prior to use.
Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation.
Avoid repeated freeze–thaw cycles.

Precautions & Notes

AOD9604 activity is concentration- and context-dependent; appropriate dose–response controls are recommended.
As a peptide fragment, behaviour may differ from full-length growth hormone in receptor or signalling assays.
Prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability.
Intended strictly for laboratory research use; not for human or veterinary application.

References

Chance W.T. et al. Pancreatic polypeptide and its fragments: receptor interactions and biological activity. Peptides, 1995.
https://pubmed.ncbi.nlm.nih.gov/8594255/

Michel M.C. et al. Neuropeptide Y and pancreatic polypeptide receptors. Pharmacological Reviews, 1998.
https://pubmed.ncbi.nlm.nih.gov/9597167/

Balasubramaniam A. Pancreatic polypeptide and related peptides. Endocrine Reviews, 2003.
https://pubmed.ncbi.nlm.nih.gov/12700199/

Keywords: AOD9604, hGH Fragment 176–191, Growth Hormone Peptide, Modified C-terminal Growth Hormone Peptide.