NAD+ 500MG

£100.00

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a fundamental redox coenzyme widely used in biochemical and cellular research to investigate cellular energy metabolism, mitochondrial function, and redox-dependent signalling pathways in experimental systems.

Batch manufactured to specification
CAS Number: 53-84-9
Molecular Formula: C₂₁H₂₇N₇O₁₄P₂

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity.
Store in a cool dark place.
Sold for research purposes only.
Contact us for Wholesale Orders.

NAD+

Synonyms / Designations: NAD+, Nicotinamide Adenine Dinucleotide (oxidised form), β-NAD+
CAS Number: 53-84-9
Molecular Formula: C21H27N7O14P2
Molar Mass: ~663.43 g/mol
Chemical Classification: Pyridine nucleotide coenzyme
Purity: 99% (HPLC, typical)
Appearance: Clear liquid
Storage: Store in a cool dark place. Discard 30 DAYS after opening.

Description & Mechanism

Nicotinamide adenine dinucleotide (NAD+) is an endogenous pyridine nucleotide that functions as a central redox cofactor and signalling molecule in cellular metabolism. In its oxidised form, NAD+ participates in electron transfer reactions fundamental to oxidative phosphorylation, glycolysis, and mitochondrial energy production.

In biochemical and cellular research systems, NAD+ is extensively studied for its role in redox balance, substrate availability for NAD+-dependent enzymes, and regulation of intracellular signalling pathways. These include sirtuins, poly(ADP-ribose) polymerases (PARPs), and cyclic ADP-ribose-generating enzymes involved in DNA repair, chromatin regulation, and calcium signalling. Experimental outcomes are influenced by intracellular NAD+/NADH ratios, compartmentalisation, and the metabolic state of the model system.

Applications in Research

Investigation of cellular redox metabolism and mitochondrial function.
Studies of NAD+-dependent enzymes including sirtuins and PARPs.
In vitro research on energy homeostasis and metabolic signalling pathways.
Use as a reference compound in enzymology and metabolic research.

Handling & Stability

Store in a cool dark place. Discard 30 DAYS after opening.
Shelf life: 30 months from production.

Precautions & Notes

Experimental behaviour of NAD+ is influenced by pH, temperature, and redox environment.
NAD+ is sensitive to hydrolysis under acidic or basic conditions.
Appropriate controls are recommended when interpreting enzyme-dependent effects.
Intended strictly for laboratory research use only; not for human or veterinary application.

References

Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science, 2015.
https://pubmed.ncbi.nlm.nih.gov/26785480/

Covarrubias A.J. et al. NAD⁺ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021.
https://www.nature.com/articles/s41580-020-00313-x

Rajman L. et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 2018.
https://pubmed.ncbi.nlm.nih.gov/29514064/

Braidy N., Liu Y. NAD⁺ therapy in age-related degenerative disorders: a benefit/risk analysis. Experimental Gerontology, 2020.
https://pubmed.ncbi.nlm.nih.gov/31606488/

Keywords: NAD+, Nicotinamide Adenine Dinucleotide, Pyridine Nucleotide, Redox Cofactor, Mitochondrial Metabolism, Enzymology, Metabolic Research