TB-500 5MG

£26.00

TB-500 is generally referenced in research catalogs as fequesetide (an active-region peptide of thymosin β4), used experimentally to investigate actin dynamics, cell migration, and repair-associated signalling pathways in controlled laboratory systems.

Batch tested Purity: ≥ 99 % (HPLC, typical)
CAS Number: 77591-33-4
Molecular Formula: C212H350N56O78S

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Reconstitution

Use bacteriostatic water. Add solvent slowly along vial wall. Do not shake gently swirl.

Cold Chain

Store lyophilised at 2–8°C. Once reconstituted, keep at 2–8°C and use within 28 days.

Certificate of Analysis

CoA available on request for each batch. HPLC and MS data provided.

Description

Batch HPLC tested at 98.5%+ purity
Store frozen long term or in fridge when ready to be used
Sold for research purposes only
Contact us for Wholesale Orders

TB-500

Synonyms / Designations: TB-500, Thymosin Beta-4 Fragment, Synthetic Thymosin β4-Derived Peptide
CAS Number: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: ~4963.0 g/mol
Peptide Length: 43 amino acids
Peptide Type: Synthetic peptide derived from thymosin beta-4
Purity: 99% (HPLC, typical)
Appearance: White to off-white lyophilised powder
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

TB-500 is a synthetic peptide derived from the active region of thymosin beta-4, developed for experimental investigation of actin-binding dynamics, cell migration, and cytoskeletal organisation in controlled research settings.

In biochemical and cellular research models, thymosin beta-4-related peptides are studied for their interaction with G-actin, influencing actin polymerisation and cytoskeletal remodelling. Observed responses depend on peptide concentration, exposure duration, cell type, and experimental conditions.

Applications in Research

Investigation of actin dynamics and cytoskeletal regulation
In vitro studies of cell migration and cellular organisation
Experimental models examining tissue structure and repair signalling
Reference peptide in thymosin beta-4-related research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide may be hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution
Avoid vigorous agitation during dissolution
Filter sterilize if required
Aliquot and store reconstituted solutions at –20 °C or lower
Avoid repeated freeze–thaw cycles

Precautions & Notes

Experimental outcomes depend on cell type and assay conditions
Buffer composition, pH, and ionic strength may influence peptide stability
Appropriate controls are recommended
Intended strictly for laboratory research use only

References

Gupta S., Paliczak A., Delgado D. Evidence-based indications of thymosin beta-4 for wound healing and tissue regeneration. Annals of the New York Academy of Sciences, 2021.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8228050/

Sosne G., Qiu P., Goldstein A.L., Wheater M. Biological activities of thymosin beta-4 defined by active sites in short peptide sequences. FASEB Journal, 2010.

https://iovs.arvojournals.org/article.aspx?articleid=2423767

Malinda K.M., Sidhu G.S., Mani H. et al. Thymosin beta-4 accelerates wound healing. Journal of Investigative Dermatology, 1999.

https://pubmed.ncbi.nlm.nih.gov/10469335/

Keywords: TB-500, Thymosin Beta-4, Synthetic Peptide, Actin Regulation, Cytoskeletal Dynamics, Research Peptide